The Science Behind Fullify

Explore the research and evidence behind Fullify's precision probiotic (Hafnia alvei HA4597®) and its role in appetite signaling and weight-related outcomes when combined with a calorie-conscious diet.*

Body weight and appetite are influenced by complex biological signals between the gut and the brain. Research increasingly shows that certain gut-derived proteins can help the brain register fullness earlier, helping people feel satisfied with less food.

 

A Controlled Study in Real People

Fullify’s key probiotic strain, Hafnia alvei HA4597®, was evaluated in a 12-week, randomized, double-blind, placebo-controlled clinical study in 218 adults following a calorie-restricted diet (-20% hypocaloric). Participants took two capsules per day providing 100 million CFU/serving.

  • Study design: 12 weeks, randomized, double-blind, placebo-controlled
  • Population: Overweight adults on a calorie-reduced diet
  • Daily dose: 2 capsules (100 million CFU) daily Hafnia alvei HA4597®
  • Setting: Multiple centers to ensure broader observations

 

Measured Changes Observed in the Study

In the study, participants taking Hafnia alvei HA4597® demonstrated differences in how their bodies responded compared to placebo when all were on a calorie-conscious diet.

  • More participants achieved meaningful reductions in body weight compared to placebo.*1
  • Participants taking the strain reported greater feelings of fullness.* 1
  • Hip circumference reductions were greater in the HA4597® group vs placebo.* 1

 

Putting Evidence Into Context

These findings suggest that supporting your body’s fullness signals with Fullify’s precision probiotic may help you feel satisfied sooner and stay on track with your calorie-conscious lifestyle.* Results are most reliable when paired with diet and lifestyle routines similar to those used in the study.

 

What Is Hafnia alvei HA4597®?

HA4597® is a precision probiotic strain researched for its role in supporting the body's natural fullness signals. It produces a bacterial protein linked to satiety pathways, which researchers believe may help enhance feelings of fullness during meals.*

 

Sources & Further Reading

  • 2021 Hafnia alvei HA4597® clinical trial — Nutrients Journal (PubMed).
  • Additional peer-reviewed articles on microbiota and appetite regulation (MicrobiomePost).

 

1. Dechelotte et al., 2021. Clinical trial in overweight adults on a calorie-restricted diet. At 12 weeks, more participants achieved statistically significant weight loss (3%-4%), reduced hip circumference by −2.8 cm vs. −1.64 cm (p < 0.001); user fullness and cravings assessed using validated visual analog scale (VAS) at baseline, week 8, and week 12.